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Volume :15 Issue : 2 1988      Add To Cart                                                                    Download

Effect of concanavalin A on the electrogenic transfer of some amino acids and hexose sugars across rat small intestine

Auther : FAWZIA Y. AL-BALOOL

Department of Zoology, University of Kuwait, P.O. Box 5969. Safat 13060, Kuwait

 

ABSTRACT

 

1. The effect of concanavalin A (Con A) on the electrogenic transfer of glucose, galactose, glycine and valine was investigated invoitro using everted sacs of the rat jejunum. The short circuit current (s.c.c.), potential difference (p.d.) and tissue resistance were also measured in the presence and absence of the drug.

2. Con A increased apparent Km for glucose, galactose, glycine and valine, decreased S.C.C. and p.d. in the presence of glucose, and inhibited sodium transport.

3. In view of the fact that oxygen consumption was unaffected, it is proposed that Con A did not act by a non-specific mechanism.

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